Nutrition Health Review - Dopamine linked to psychosis - Medical News From Around The World - Brief Article
TAIWAN–As reported in Annals of Pharmacotherapy (September 2002), symptoms of psychosis developed in two patients after treatment with the dopamine receptor antagonist metoclopramide.
One of the patients, a 65-year-old man, had been given metoclopramide for gastric stasis. He had a history of cerebrovascular accident (CVA) and hypertension, but he had never shown any signs of psychosis in the past. Once his gastric symptoms improved, metoclopramide was discontinued. Three days later, he began to experience hallucinations, delusions, anxiety, and agitation along with dizziness and nausea. Risperidone, 1 milligram a day, was prescribed to treat the psychosis, and the symptoms did not recur.
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The other patient, a 74-year-old man with a history of diabetes and CVA, took metoclopramide for gastrointestinal discomfort. After six months, metoclopramide was discontinued; within 12 hours, he experienced anxiety, restlessness, sleep disturbance, and hallucinations. After three days of these symptoms, he underwent a psychiatric evaluation. Once again, risperidone was prescribed and his psychosis symptoms ended.
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