Journal of the American Academy of Child and Adolescent Psychiatry - A randomized, double-blind, placebo-controlled trial of metoclopramide for the treatment of Tourette’s disorder.
Tourette’s disorder, with a prevalence of 1% to 3% of children and adolescents (Robertson, 2003), is a chronic, childhood-onset neuropsychiatric illness. It is characterized by motor and vocal tics that fluctuate in severity and can be socially and physically impairing for some children and adolescents.
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Dopamine antagonists have been widely used in the treatment of tics and are considered the most effective pharmacological treatments for tics (Jankovic, 2001). Although the efficacy of the typical dopamine antagonists, particularly haloperidol and pimozide, has been …
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