Clinical Psychiatry News - Metoclopramide treats Tourette’s
A daily dose of metoclopramide decreased tic severity by 38.7% in children aged 7-18 years with Tourette’s disorder, compared with a 12.6% reduction in a placebo group, reported Rob Nicholson, M.D., of the University of Western Ontario in London, and his colleagues.
In a randomized, double-blind, placebo-controlled study of 27 children, 14 received metoclopramide starting at 5 mg daily, titrated as needed to a maximum 40-mg daily dose, and 13 received a placebo (J. Am. Acad. Child Adolesc. Psychiatry 2005;44:640-6).
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The average dose after 8 weeks was 32.9 mg. Adverse events were mild; the most common was increased appetite, but weight gain did not differ significantly from that in the placebo group. One patient had a 30-fold increase in prolactin levels that resolved with discontinuation of the drug at the study’s end.
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