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Some researchers estimate that Restless leg syndrome affects as many as 12 million Americans.

RLS was once thought to be due to disease in the blood vessels of the legs or in the nerves in the legs that control leg movement and sensation. Both of those suggestions have been rejected. RLS occurs in both genders, although the incidence may be slightly higher in women. Symptoms may begin at any stage of life, although the disorder is more common with increasing age.

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